Colombian Researchers Study Potential for SIS-Based Photocrosslinking in Bioinks
Colombian researchers performed a recent study, outlined in ‘Formulation and Characterization of a SIS-Based Photocrosslinkable Bioink,’ explaining the possible value in crosslinking to create better materials for 3D printing cells. Here, they are using small intestinal submucosa (SIS) with photocrosslinked reactions to manipulate the gelation process, despite some expected challenges.
While the use of natural materials is always preferable, the researchers point out that they can also be difficult to work with due to lack of strength and stability. In the end that leads to inferior printability and further challenge.
The authors also began to study decellularized extracellular matrices (dECMs) further, as they have the potential to copy the natural cellular environment. dECMs include the following proteins:
dECMs are not always stable though, and that presents challenges in bioprinting:
UV light has been used previously to increase the bioink stiffness in photocrosslinking, and for this study the authors experimented with the SIS dECM-based materials, using riboflavin (RF) as a photoinitiator. Visible light was used for the photocrosslinking. The research team created four different types of bioinks, with successful printability.
They also went on to state that these bioinks demonstrate strong mechanical properties that could ensure success in bioprinting endeavors—following in line with previous research studies where crosslinking resulted in excellent printability parameters, as well as offering better integrity in shape.
The study of materials in 3D printing has become a vast realm, and a necessary one for those dedicated to such progressive fabrication techniques. It is also a very serious area of study for scientists engaged in seeking out the best ways to grow tissue in the lab, with the potential for making serious impacts in medicine.
Researchers around the world are on an intense journey to perfect bioprinting, and eventually, reach the pinnacle of success in fabricating human organs. The challenge today, as tissue engineering results in a variety of different implants, is to keep cells alive to serve their function in bioprinting. This means seeking out the best bioprinted structures to build, bio-inks, printers, and techniques. Find out more about photocrosslinkable inks here. What do you think of this news? Let us know your thoughts! Join the discussion of this and other 3D printing topics at 3DPrintBoard.com.
[Source / Images: ‘Formulation and Characterization of a SIS-Based Photocrosslinkable Bioink’
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April 15, 2019 at 03:33AM